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< class="article__title title lions-mane-for-neuropathy-does-lions-mane-help"> Lion's Mane for Neuropathy: Does Lion's Mane Help?>
Lion's Mane for Neuropathy: Does Lion's Mane Help?
Aug 01, 22
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Author: Sony Sherpa

Lion's Mane for Neuropathy: Does Lion's Mane Help?

  • by Sony Sherpa

    Medically reviewed by

    Sony Sherpa

    Dr. Sony Sherpa is a board-certified Clinical Doctor and dedicated advocate for holistic medicine, specializing in functional mushrooms. Her blend of medical expertise and passion for alternative wellness lends authenticity to her role as a contributor for Natures Rise.

  • |
  • 13 min read
Lion's Mane for Neuropathy: Does Lion's Mane Help?

Lion's mane mushroom (Hericium erinaceus) is a fungus with a long history in traditional Eastern medicine, known for its potential neuroprotective and neuroregenerative properties. Research suggests that lion's mane may help alleviate neuropathy symptoms, a condition characterized by nerve damage and dysfunction, by promoting nerve growth factor (NGF) production and reducing inflammation. 

With increasing interest in natural remedies, lion's mane has emerged as a promising alternative due to its ability to promote peripheral nerve regeneration, offering hope to those suffering from peripheral nerve injury and other neuropathy symptoms. However, its efficacy in treating neuropathy remains to be explored through more extensive clinical trials. 

In this article, we delve into the science behind lion's mane's potential benefits for neuropathy and explore how to incorporate it into your diet. So please stick with us to learn how to improve your nerve health. 

Understanding Neuropathy: Definition and Causes

Understanding Neuropathy: Definition and Causes

Neuropathy is a broad term that encompasses a variety of peripheral nerve disorders resulting from damage to the nerve cells in the peripheral nervous system, which lies outside the brain and spinal cord. 

There are several causes of neuropathy, including diabetic neuropathy, chemotherapy-induced peripheral neuropathy, and idiopathic neuropathy:

  • Diabetic neuropathy is a common diabetes complication affecting the peripheral nerves due to prolonged exposure to high blood sugar levels. 
  • Chemotherapy-induced peripheral neuropathy arises as a side effect of certain cancer treatments, causing nerve damage and hindering nerve repair. 
  • Idiopathic neuropathy, on the other hand, occurs when the exact cause of the nerve damage remains unknown.

Interesting Read: See how Lion's Mane fights diabetes.

Symptoms and Progression of Nerve Damage

Neuropathy symptoms can range from mild cognitive impairment to severe pain and loss of hind limb function. The condition's progression varies depending on the underlying cause and the affected peripheral nerves. 

Common symptoms include numbness, tingling, weakness, and pain in the hands and feet, which may spread to other body parts. The nervous system is a complex network of nerve cells, and when peripheral nerve injuries occur, they can significantly impact daily life.

Current Treatment Options and Their Limitations

Current treatment options for neuropathy are often limited in effectiveness and may not address the root cause of the nerve damage. Conventional neuropathy treatment includes pain management, blood sugar control for diabetic patients, and addressing vitamin deficiencies. However, these treatments might not be sufficient to restore peripheral nerve function or promote peripheral nerve regeneration.

This is where the potential benefits of Hericium erinaceus, commonly known as lion's mane mushroom, come into play. Studies have shown that lion's mane may stimulate nerve growth and support the repair of damaged nerve cells in both the brain and peripheral nervous system. 

Its unique compounds, such as hericenones and erinacines, have been linked to nerve development and growth, improving mild cognitive impairment and protecting against further nerve damage. Additionally, Hericium erinaceus has been suggested to improve brain functions, aid in the recovery of peripheral nerve injuries, and enhance spinal cord healing after peripheral nerve injury. 

Lion's Mane for Neuropathy: What Does The Science Say?

Lion's Mane for Neuropathy: What Does The Science Say?

Neuroprotective and Neuroregenerative Properties

Lion's mane mushroom (Hericium erinaceus) has been studied for its potential neuroprotective and neuroregenerative properties. These properties can be attributed to two key factors:

Promotes Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF) Production

Lion's mane mushrooms contain bioactive compounds that stimulate the production of nerve growth factors, such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). 

These proteins play a crucial role in the survival, growth, and maintenance of nerve cells in the central and peripheral nervous systems. By promoting nerve growth, lion's mane may help to repair damaged peripheral nerves, alleviate nerve pain, and improve muscle weakness associated with neuropathy.

Interesting Read: See how Lion's Mane neurogenesis promotes NGF and BDNF production

Activates the Nrf2 Pathway

Research has shown that(1) Hericium erinaceus may activate the Nrf2 pathway, which protects nerve cells from oxidative stress and inflammation. This activation can support healthy nerves and overall brain health.

Anti-Inflammatory and Antioxidant Effects

Lion's mane mushrooms possess potent anti-inflammatory and antioxidant properties that may help reduce neuropathic pain and protect nerve cells from further damage. These health benefits are significant for individuals suffering from chronic pain caused by nerve damage.

Studies and Clinical Trials

Animal Studies

Several animal studies have demonstrated the potential of Lion's Mane medicinal mushroom in promoting nerve regeneration and reducing neuropathic pain. For instance, administering an aqueous extract of Hericium erinaceus has improved nerve growth and function in rodents with peripheral nerve injuries, such as damage to the dorsal root ganglia nerves.

In a 2019 study(2), researchers examined the impact of Lion's mane medicinal mushrooms on drug-induced peripheral neuropathy in mice. In this animal-based study, those given the mushroom showed fewer signs of neuropathy than those who did not consume Lion's mane.

Another animal study explored(3) the neuro-regenerative potential of extracts of Lion's mane in the treatment of peripheral nerve injuries. In the study, researchers compared the effects of Hericium Erinaceus with one of the most commonly used treatments for peripheral nerve injury: vitamin B12. Again, results showed that Lion's mane mushroom elicited quicker nerve regeneration.   

Human Trials

Limited human trials have also shown promising results. For example, one study found that(4) lion's mane mushroom extract improved cognitive functioning and reduced mild cognitive impairment in older adults. Another study found that(5) Hericium erinaceus supplementation could alleviate neuropathic pain by enhancing blood vessels and immune system function.

Interesting Read: See how Lion's Mane fights blood pressure.

Limitations and Future Research

Despite the encouraging results, there are limitations to the current body of research on lion's mane mushrooms and neuropathy. Most studies have been conducted on animals, and human trials are scarce. Additionally, many studies have used aqueous extracts of lion's mane, which may not accurately represent the effects of consuming whole lion's mane mushrooms or lion's mane extract supplements. 

Further research is needed to determine the optimal dosage, duration, and form of lion's mane for treating peripheral nerve disorders and better understand how Hericium erinaceus interacts with the blood-brain barrier and affects brain function.

How to Incorporate Lion's Mane into Your Diet

How to Incorporate Lion's Mane into Your Diet

Incorporating lion's mane mushrooms into your diet may help treat peripheral nerve disorders and support overall brain function. Here's how to add this medicinal mushroom to your daily routine:

Lion's Mane Dosage for Neuropathy

Research has not been done to determine the ideal Lion's mane dosage for fighting neuropathy. However, we recommend talking to a healthcare professional before using Lion's Mane—this should help you determine the ideal dosage depending on your health status and body requirements. 

On average, however, you can take 2,000 mg daily. Consider starting with a 1,000 mg daily dosage. You can increase the quantity as your body becomes used to the mushroom. 

Lion's mane is not known to cause significant side effects when used at the proper dosage. However, immediately seek the doctor's attention if you notice any side effects. 

Choosing the Right Lion's Mane Supplement

Powder vs. Capsules vs. Extracts

Various forms of lion's mane mushroom supplements are available, including powders, capsules, and extracts. Lion's mane mushroom powder can be easily mixed into smoothies, teas, and other beverages, while capsules provide a convenient daily oral administration option. Extracts are a concentrated form of the mushroom's beneficial compounds, which may offer more potent effects.

Interesting Read: See the difference between lion's mane powder and extracts.

Quality and Purity Considerations

When selecting a lion's mane supplement, it's essential to consider quality and purity. Look for products from reputable manufacturers that use organic, non-GMO medicinal mushrooms and provide transparent information about their sourcing and processing methods.

Recipes and Ideas for Incorporating Lion's Mane


You can use Lion's mane powder in smoothies to support nerve regeneration and overall health. Combine lion's mane mushroom powder or extract with fruits, vegetables, and a liquid base for a nourishing and delicious drink.

Teas and Coffees

Add lion's mane mushroom powder or extract to your favorite hot beverages, such as tea or coffee, for a brain-boosting twist. This simple addition may help stimulate NGF synthesis, promote neurite outgrowth, and support immune function.

Culinary Dishes

Lion's mane mushrooms have a mild, slightly sweet flavor and a tender, meaty texture, making them a versatile addition to various dishes. Try sautéing fresh lion's mane mushrooms in a stir-fry, incorporating them into a pasta sauce, or using them as a meat substitute in vegetarian dishes. 

This delicious and nutritious ingredient can help with peripheral nerve issues, providing immune support and promoting functional recovery. Incorporating lion's mane mushrooms into your diet can be an enjoyable way to support nerve regeneration and maintain overall health. 

Interesting Read: See these Lion's mane mushroom recipes to prepare healthy meals at home.

Lion's Mane Neuropathy Video

FAQs About Lion's Mane Neuropathy

Can Lion's Mane Regenerate Nerves?

Lion's mane (Hericium erinaceus) is a medicinal mushroom that has shown promising results in promoting nerve regeneration in both animal studies and limited human trials. Its bioactive compounds, such as hericenones and erinacines, stimulate nerve growth factors (NGF) and brain-derived neurotrophic factor (BDNF) production. These proteins are crucial for the survival, growth, and maintenance of nerve cells in the central and peripheral nervous systems.

Animal studies have demonstrated that lion's mane supplementation can improve the function and growth of peripheral nerves in rodents with peripheral nerve injuries. In addition, in vitro studies have also shown that lion's mane extracts can promote neurite outgrowth, the process by which nerve cells extend new projections to communicate with other cells. 

These results suggest that these medicinal mushrooms may have a positive and beneficial impact on the central nervous system, fighting nerve damage and improving the health of the brain cells. 

Are There Negative Effects Of Lion's Mane?

Lion's mane (Hericium erinaceus) is generally considered safe when consumed moderately. However, as with any supplement or natural remedy, some individuals may experience side effects. Some potential side effects of mushroom supplements containing lion's mane include:

  • Allergic reactions: Some people may be allergic to lion's mane or its components, resulting in itching, rashes, or difficulty breathing. 
  • Upset stomach: Some individuals may experience gastrointestinal discomforts, such as bloating, gas, or diarrhea, after consuming lion's mane, especially in more significant amounts.
  • Drug interactions: Lion's mane may interact with certain medications, such as blood thinners or diabetes meds because it lowers blood sugar levels and affects blood clotting. 

Consult a doctor before adding lion's mane to your routine, especially if you have pre-existing medical conditions or are taking medications. Start with a small dosage to assess your tolerance and adjust the dosage as needed.

Key Takeaways

Lion's mane (Hericium erinaceus) is a unique medicinal mushroom with promising potential in addressing neuropathy through various mechanisms. 

Its neuroprotective and neuroregenerative properties, attributed to the stimulation of nerve growth factors like NGF and BDNF, may help repair damaged nerve cells and promote nerve growth. Additionally, the mushroom's anti-inflammatory and antioxidant effects could aid in reducing neuropathic pain and protecting nerve cells from further damage. 

Although limited human trials have demonstrated some positive effects of lion's mane on neuropathy and cognitive functioning, more research is needed to fully understand its impact on peripheral neuropathy and the optimal dosage and form for human consumption.

If you consider incorporating lion's mane into your routine for neuropathy management, consult a healthcare professional to determine if it is appropriate for your specific needs and circumstances. Remember that lion's mane should not replace conventional neuropathy treatments but may be complementary to support nerve regeneration and overall nerve health. 

Have you used Lion's Mane mushrooms before? How did these medicinal mushrooms help you? Please share with us in the comment section. 

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  1. Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells, (1) 
  2. Healing effect of Hericium erinaceus in experimental peripheral neuropathy model. (2)
  3. Neuroregenerative potential of lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review), (3) 
  4. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial, (4) 
  5. Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines(5)

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