Mushroom Benefits For Skin: Top 3 Mushrooms to Improve Skin Health

We are familiar with them for their adorable umbrella shape, health benefits, and delicious culinary uses—but mushrooms in skincare? Yes, there is a mushroom boom in beauty routines as mushroom skin care popularity continues to rise.

Reishi and Chaga mushrooms, two of the most well-known mushrooms today, have been used in skin care products and dietary supplements for more than 2000 years. Mushrooms have roots in traditional eastern medicine and are linked to reviving vitality, addressing imbalances, boosting weakened immunity, treating hypersensitive skin, and lowering inflammation.

Medicinal mushrooms are also beneficial in various skin conditions, from acne and Psoriasis to skin whitening. In addition, mushrooms are "adaptogens" that can help our bodies resist or "adapt" to stress, resulting in healthier and more radiant skin.

But which mushrooms will help address your specific skin concerns, and what are the mushroom benefits for skin? Let's find out.

Here are the highly recommended mushrooms you can try for their skin-supporting benefits. And you can thank us later!  

Mushroom Extract For Skin Care

Stir-fry, toppings for pizza superstar, hamburger substitute: Mushrooms have established themselves as a culinary (and highly nutritious) delight in the food industry.

Read More: Planning to cook some mushrooms? You can use our handpicked Lion's mane mushroom recipes.

However, using mushrooms on the skin may not be the first thing on your mind. Don't worry; you are not alone—it is very rare for people to assume that medicinal mushrooms can improve skin tone, facilitate skin brightening, or even fight dry skin. 

However, as recent evidence has revealed, mushrooms can be an ideal solution for many skin problems that affect us. With more scientific proof that mushrooms can fight skin aging, treat sensitive skin, and protect skin health, functional fungi are becoming available in products that are easier to use on our skin. 

For example, in addition to being available in various supplement forms, mushrooms are now showing up in topical serums, lotions, and creams targeting multiple skin conditions.But feel free to include mushrooms in your daily diet if you're the type who would instead consume them than use topical skin care products. Or, even better, use the appropriate medicinal mushroom powder that is simple to incorporate into food or drink.

Read More: Planning to use Chaga powder in your tea to improve your skin health? First, learn about the Chaga tea taste. 

What do mushroom extracts contain?

Mushrooms contain several skin-supporting compounds and ingredients such as lentinan, ceramides, resveratrol, and carotenoids. Other bio compounds in the mushroom that can address skin concerns and help you look radiant are Melanin, antioxidants, beta-glucans, fatty acids, and L-ergothioneine. Below we will explore each compound in detail. 

Melanin

Melanin determines the intensity of pigments in our hair, skin, and eyes. It is also in charge of preserving the health and protection of our skin. 

Melanin can help shield our skin from UV ray damage(1). It accomplishes this by absorbing UV rays before they cause skin cell deterioration.

Read More: Did you know that mushrooms can improve your hair health? See how Chaga mushroom enhances hair health. 

Additionally, melanin(2) has anti-inflammatory and free radical scavenging qualities. Its antioxidant properties can help stop the oxidative stress that causes early aging and skin damage.

Antioxidants

Antioxidants(3) are crucial for preserving cellular health and fostering longevity, as we've all heard. However, one additional benefit of antioxidants is their capacity to rejuvenate your skin. This is possible due to their ability to combat free radicals, which result in oxidative stress and harm healthy cells, this is possible.

Antioxidants combat free radicals by interfering with the intracellular signaling pathways that result in skin damage. In addition to addressing skin irritability and wrinkle appearance, this can help prevent sun damage.

Beta-glucans

The cell walls of mushrooms contain beta-glucans. As a result, they boost immune system strength by promoting macrophage production. 

Scavenger cells called macrophages hunt down and eliminate harmful bacteria. In addition, numerous studies on animals have suggested that beta-glucans, through interactions with critical immune cells and cytokines, may hasten the healing of wounds(4).

Beta-glucans(5) also contains a lot of antioxidants, which, as we discovered in the earlier section, can assist in stopping the oxidative stress that results in premature aging and wrinkles.

L-ergothioneine

L-Ergothioneine is a powerful amino acid that occurs naturally in your body and is also in large amounts in edible mushrooms. Because of its potent antioxidant properties, it can lessen oxidative stress and increase the lifespan of healthy skin cells.

According to research on human skin cells(6), the amino Acid may also aid in repairing DNA and sun-damaged skin cells. As a result, l-ergothioneine can be incorporated into your beauty routine to help rejuvenate dull skin and keep your complexion resistant to aging and environmental damage.

Kojic Acid

While Kojic Acid is often produced by fermenting certain foods, including rice wine, soy sauce, and Japanese Sake, it is also found in several fungi. Kojic Acid prevents—or inhibits—the formation of tyrosine, an amino acid with a vital crucial role in melanin production. 

Melanin is a pigment that affects hair, eye, and skin color, often giving it a darker complexion. Because Kojic Acid inhibits the production of Melanin, many people often use skin care products with Kojic Acid for skin lightening. 

The primary use —and benefit—of Kojic Acid is to help users lighten visible signs of sun damage, aging spots, and scars. In addition, the Acid may produce an anti-aging effect on the user's skin, allowing them to look more youthful. 

In addition to having skin-lightening capabilities, kojic Acid does feature some antimicrobial properties. This compound may be effective against several common bacterial strains, even at low concentrations. This can aid in acne treatment in cases where bacteria on the skin cause acne. It may also lighten acne scars that haven't faded yet.

Research shows that(7) Kojic Acid has antifungal properties as well. It's even added to some antifungal products to boost their potency. In addition, it may treat fungal skin infections, including yeast infections, candidiasis, ringworm, or athlete's foot. Regular use of Kojic Acid soap may help prevent bacterial and fungal infections in the body.

While Kojic Acid is present in various mushrooms, shiitake mushrooms contain this compound in the highest amounts. Therefore, consuming Shiitake mushrooms at a doctor-approved dosage will allow you to leverage the benefits of Kojic Acid on acne-prone skin. 

Hyaluronic Acid

Hyaluronic Acid is another impressive compound that lets mushrooms benefit skin health. Hyaluronic Acid carries several skin health benefits, including: 

• It keeps your skin hydrated. Hyaluronic Acid is highly effective at retaining water. As a result, hyaluronic Acid is frequently used as an effective treatment for dry eyes. You may find it in your favorite moisturizer, lotions, ointments, and serums.
• It makes your skin more pliable. Hyaluronic Acid allows your skin to flex and stretch while reducing wrinkles and lines. Hyaluronic Acid has also been shown to speed up wound healing and reduce scarring.

While Hyaluronic Acid may be present in various mushrooms, it is more common in the snow mushroom. By helping the skin heal faster and eliminating dryness and blemishes, Hyaluronic Acid restores radiance to your skin, softening it and making it look more youthful. 

Vitamin D

When most of us think of vitamin D, the first benefit we associate it with is stronger bones. However, vitamin D carries more benefits than just improving your bones and allowing the body to absorb calcium. 

Vitamin D regulates the production of keratinocytes, cells found in the epidermis, the outermost layer of your skin. These cells are vital for the optimal performance of your skin barrier. 

The skin barrier keeps harmful germs and chemicals out of your skin and helps lock in moisture to prevent skin dehydration. Therefore, avoiding dry skin becomes extremely easy when you have enough vitamin D. 

Skin is the largest protective organ and one of the most critical components of your body's first line of defence. Vitamin D is required to activate immune cells like macrophages and monocytes. These innate immune system cells are critical in identifying and combating any foreign substance that enters your body through your skin.

Vitamin D is also necessary for regulating B and T cells, the two main components of the human adaptive immune system. Overactivity of these cells can result in autoimmune diseases.

According to scientific research, vitamin D is essential for growth regulation and optimal functioning of the skin's sebaceous gland cells. In addition, Sebum is a natural oil secreted by the sebaceous glands, forming a protective layer on the skin's surface.

The topical application of vitamin D3 has been shown to protect the skin from UV light damage.To some extent, vitamin D reduces cell death, promotes cell survival, and reduces redness caused by UV radiation photodamage of the skin.

It has been demonstrated that vitamin D increases the expression of the protein cathelicidin. This antimicrobial protein promotes tissue repair and the restoration of the skin's barrier mechanism. As a result, it is critical for the healing of skin wounds.

If you are wondering where to get your vitamin D to enjoy the skin benefits mentioned above, consider including mushrooms in your nutrition. According to a research study conducted in 2018(8), mushrooms contain the highest levels of vitamin D in the plant family. In addition, the research study noted that mushrooms could provide the level of vitamin D recommended for daily consumption. 

Best Mushrooms For Skin Health

Reishi Medicinal Mushrooms

While some people are familiar with the health benefits of Reishi mushrooms, not many know that this functional fungus can improve their skin too. Below, we will look at the reasons why more people are eating mushrooms (reishi mushrooms in this case) to improve their skin health: 

Reishi Mushrooms Facilitates Skin Whitening

Ganoderma or Reishi mushroom is one of the best mushrooms for skin whitening. By preventing the skin cells from producing melanin(9), they can treat the dark spot on the skin. Many skin-lightening products contain Reishi extracts because they reduce skin pigmentation.

Reishi's ability to inhibit the production of Melanin has been confirmed by various research studies. A research paper published in 2016(10) labeled Reishi mushroom a melanogenesis inhibitor—the study noted that Reishi inhibits the production of Tyrosinase, which is responsible for facilitating melanin production. 

Reishi Fights Aging

Reishi is thought to be a potent, naturally occurring anti-aging fungus. The mushroom's lysine strengthens the skin's elasticity and support, giving it a visibly firm appearance.

The mushroom's high polysaccharide content renews and repairs the skin. In addition, polysaccharides support the body's natural immune system and response to inflammation. 

These antioxidant and anti-inflammatory properties increase cell turnover and reduce the appearance of fine lines. As a result, the mushroom lessens wrinkles, skin inflammation, puffiness, and free radical-induced skin damage. 

Additionally, it keeps water inside the skin, keeping it hydrated. The likelihood that skin will react to environmental stressors decreases as hydration increases. The polysaccharide found in mushrooms also encourages skin renewal.

Several research studies have confirmed Reishi's abilities to fight aging. For example, a research study published in 2017(11) established the mushroom's role in preventing aging. 

A second research study conducted in 2019(12) used an animal model to analyze the potential of reishi mushrooms in fighting aging. The research study concluded that mushroom is extremely effective in delaying aging. 

Read More: Interested in taking advantage of Reishi's anti-aging benefits? Be sure to use the best Reishi mushroom dosage.

Reishi Fights Acne

Reishi is also one of the best mushrooms for acne. Amino acids found in peptidoglycans from Reishi mushrooms aid in synthesizing antimicrobial peptides. It also has anti-inflammatory(13) and immunomodulatory qualities that can help with acne, an inflammatory skin condition brought on by bacterial infection.

The mushroom also controls the androgen hormone, which causes female cyclical acne. The nervous system will be calmed, and the body's resistance to stress will be increased by balancing androgens. Reishi's capacity to restore hormonal equilibrium stops the androgen-driven breakout in the chin, jaw, neck, and upper back.

Read More: See how Reishi promotes hormonal balance.

Reishi Fights Psoriasis

Psoriasis is when skin cells accumulate, forming scales and itchy, dry patches. Psoriasis is thought to be a problem with the immune system. Infections, stress, and the common cold are all triggers. The most common sign is a skin rash, but the inflammation can also affect the nails or joints.

The treatment aims to remove scales and slow the growth of skin cells. Treatment options include topical ointments, light therapy, and medication.

However, Reishi is also our top pick for mushroom for Psoriasis in the holistic health department, especially in cases where the condition results from oxidative stress. In a 2020 study(14), researchers looked into whether the ganoderic acids in Reishi could shield cells from hydrogen peroxide-caused cell damage.

More than 35% of cells in this experiment died after exposure to hydrogen peroxide. Reishi mushroom alcohol extract reversed this trend and reduced the damage brought on by oxidative stress to 15%. 

This study indicates that in addition to providing anti-inflammatory benefits and improving dehydrated skin, the Reishi mushroom can fight free radical damage, which often causes Psoriasis. 

Reishi Fights Skin Cancer

According to the American Academy of Dermatology (AAD)(15), skin cancer is the most common cancer in the United States. AAD estimates that one in five Americans will develop skin cancer in their lifetime. AAD also notes that approximately 9500 people are diagnosed with skin cancer daily. Luckily, however, research shows that the Reishi mushroom has anti-cancer benefits. 

A 2014 study(16) examined Reishi's effects on highly invasive breast cancer cells. The reishi mushroom inhibited tumor cell metastasis from the breast to the lungs by downregulating invasion-related genes. While this study was conducted on breast cancer, it shows that Reishi has the potential to fight skin cancer cells. 

Another research study conducted in 2022(17) analyzed the effectiveness of the Reishi mushroom in fighting skin cancer. The researchers concluded that the Reishi mushroom could prevent the development of skin cancer by attenuating Ultra-Violet induced immunosuppression. 

Reishi Mushroom Fights Diabetes

Research has shown that diabetes is often a precursor to many skin problems. For example, a research study conducted in 2017(18) determined that diabetes can cause the following skin diseases: 

• Acanthosis nigricans – This is a hyperchromic skin thickening with a velvety appearance that primarily affects folds, particularly in the armpits.
• Diabetic dermopathy – Skin lesions caused by diabetes
• Sclerodermiform disorders – These are distinguished by the thickening and stiffness of the skin surrounding the finger's dorsum and the skin covering the hand and finger joints.

Reishi organic mushrooms help people with diabetes improve their skin's natural ability to fight infections by controlling their blood sugar levels. This assists diabetics in maintaining healthy skin.

Read More: See how Reishi helps with diabetes treatment.

Reishi Fights High Blood Pressure

In 2020, a study examined(19) the relationship between high blood pressure and skin health. According to the study's findings, high blood pressure can cause wrinkles in the skin.

Reishi can aid in hypertension treatment for people with elevated blood pressure levels. A research study conducted in 2018(20) analyzed the hypotensive benefits of the Reishi mushroom. 

To investigate the antihypertensive properties of Reishi, the researchers administered Reishi water extract intragastrically to adult male hypertensive ISIAH (inherited stress-induced arterial hypertension) rats.

Reishi therapy reduced blood pressure in experimental animals to levels comparable to losartan (losartan is a pharmaceutical drug commonly prescribed to people with high blood pressure) after seven weeks. 

Reishi reduces the risk of premature skin aging and wrinkling by normalizing blood pressure levels in people with hypertension. 

Read More: See more ways Reishi improves skin health. 

Chaga Therapeutic Mushrooms

Chaga is another impressive mushroom that helps fight a variety of skin concerns, including hyperpigmentation. Extracts of Chaga mushrooms are nowadays common in high-end cosmetics, makeup, moisturizers, and cream and often generate results for almost all skin types. 

Below, we will examine the benefits of including Chaga in your skincare routine. 

Chaga Fights Eczema

Chaga or Inonotus obliquus is amongst the best mushrooms for eczema. This is an inflammatory condition of the skin, and Chaga's anti-inflammatory properties(21) can reduce eczema-related skin inflammation. In addition, your skin gets a protective film that stops moisture loss, promoting healing and relieving dry, irritated, and itchy skin.

Chaga Fights Psoriasis

Psoriasis is an autoimmune and inflammatory condition. It is well known that Inonotus Obliquus mushrooms have anti-inflammatory, anti-autoimmune, and stress-relieving properties, making them one of the best mushrooms for Psoriasis.

A 2019 study(22) looked at the effects of Chaga on psoriasis-prone mice. Inonotus obliquus naturally contains sterol betulinic acid, which has no systemic toxicity. In addition, the Acid's anti-inflammatory, antioxidant, and anti-fibrotic properties can control immunity.

Researchers discovered that betulinic acid treatment reduced inflammatory skin lesions and psoriatic symptoms in mice given Chaga extracts. Additionally, it raised blood levels of anti-inflammatory cytokines.

Read More: Read our detailed guide explaining how Chaga fights Psoriasis.

Chaga Prevents Sun Damage

Sun damage is one of the leading causes of dull skin. Interestingly, Chaga mushrooms can protect your skin from the sun's ultraviolet (UV) rays. UV rays can cause dark spots and even skin cancer.

Chaga, in addition to other beneficial nutrients, carries bioactive compounds that accelerate the production of Melanin. A research study conducted in 2014(23) showed that some of the compounds in Chaga accelerate the production of Melanin.  

Melanins are skin pigments that absorb UV rays. It protects and shelters the skin from harmful UV rays and sun rays. Using Chaga skincare products or eating mushrooms can help reduce the effects of prolonged sun exposure.

Chaga Facilitates Skin Rejuvenation

Nobody wants premature aging, skin discoloration, or other unappealing skin conditions. But unfortunately, harmful UV rays and free radicals frequently cause premature skin aging. Fortunately, Chaga provides excellent skin support for these people, reducing premature aging.

The cream made from Chaga mushrooms is high in Betulinic Acid. Betulinic Acid promotes skin health. Regular use of Betulinic acid-containing skincare products gives the skin a more youthful appearance.

Betulinic Acid also aids in the regeneration and restoration of the skin. This will help restore the skin's natural appearance, especially if it is scarred or injured.

Chaga Fights Skin Cancer

Chaga is one of the most effective anti-cancer mushrooms—the mushrooms' benefits in fighting cancer have been confirmed by researchers. For example, in a research study conducted in 2016, researchers analyzed Chaga's anti-cancer benefits using a mouse model. 

The Chaga mushroom extract had a significant tumor suppressive effect in the two models. In tumor-bearing mice, the cancer was reduced by 60%, while in metastatic mice, the number of nodules was decreased by 25% compared to the control group. 

Furthermore, mice treated with Chaga extract showed an increase in tumor agglomeration and inhibition of vascularization. Interestingly, Chaga consumption decreased body weight in middle-aged mice while increasing body temperature in mature adult mice in response to light-dark switching. In addition, Chaga prevented temperature drops in mice following tumor implantation.

The researchers concluded that Chaga mushrooms could be used as an effective natural cancer treatment. 

Read More: See how Chaga fights cancer. 

Chaga Fights Acne

The anti-inflammatory properties of Chaga allow the mushroom to fight acne.Chaga's acne benefits include moisturization, clogging prevention, and the removal of dirt.

While it is tempting to believe that this benefit is only available when Chaga mushroom is applied topically, this is not the case. When consumed as a beverage or food, the mushroom can also help with acne.

Chaga Maintains Skin Elasticity

The ability of the skin to stretch back into its original shape is called elasticity. Skin elasticity loss, often caused by aging, can result in leathery, creepy, and saggy skin.

Collagen is the skin's main structural protein. It fortifies the skin while also providing elasticity and hydration. One of the advantages of Chaga extract is that it aids in the restoration of elasticity—the mushroom helps increase skin elasticity, protecting skin from aging too quickly. 

Many factors, including sun damage and diabetes, can degrade and reduce collagen synthesis. Conversely, Chaga stimulates collagen production, restoring skin elasticity.

Chaga mushroom also contains Kojic Acid, which helps to keep skin hydrated and nourished. These acids keep your skin moist by reducing dirt buildup and clogging.

Betulinic Acid found in Chaga mushrooms is also very effective at restoring skin elasticity and a natural youthful appearance. 

Read More: See our detailed guide on how Chaga improves skin health. 

Cordyceps Functional Mushrooms

Cordyceps is another impressive functional fungus that carries many benefits for our skins. From helping reduce skin-damaging inflammation to helping you improve skin tone, below we will look at the various ways cordyceps improves your skin health. 

Cordyceps Balances Hormone Production

Cordyceps are known to affect the endocrine system and the hormones they secrete. Although this has a broader impact on metabolism, energy, and reproductive health, it also shows up in our skin.

Estrogen stimulates the production of collagen, elastin, and Hyaluronic Acid, which keeps the skin plump and firm. Progesterone stimulates the production of Sebum, produced by the skin's oil glands. It can cause the skin to swell and make pores appear smaller. However, too much of it can lead to oil buildup.

By balancing out the hormones in our bodies, Cordyceps keeps these hormones from wreaking havoc on our skin health. 

Read More: See the best mushrooms for promoting hormonal balance.

Cordyceps Has Anti-Aging and Anti-Inflammatory Properties

It is a powerful antioxidant mushroom that has fantastic anti-aging and anti-inflammatory properties. Various research studies have analyzed and proven the anti-aging properties of cordyceps mushrooms. 

According to one study(24), mice given Cordyceps lived several months longer than mice given a placebo. Another study discovered(25) that Cordyceps increased the lifespan of fruit flies, lending credence to the notion that they have anti-aging properties. 

These anti-aging benefits of Cordyceps mushrooms will also impact skin health positively, fighting wrinkles and keeping the skin youthful. 

Cordyceps Supports Health Circulation and Nutrient Delivery

Through its role in promoting healthy heart and circulation, Cordyceps enhances the health of skin cells. It supports the healthy delivery of nutrients to our skin cells by improving vasodilation and the release of nitric oxide inside the blood vessels.

Cordyceps Fights Skin Cancer

Like Chaga and Reishi mushrooms, Cordyceps is also effective in treating cancer. Various research studies have proven Cordyceps is effective in fighting Melanoma, the most common form of skin cancer. 

In a research study conducted in 2014(26), researchers analyzed the impact of cordyceps mushrooms on Melanoma. The researchers determined that Cordyceps militaris extract inhibits angiogenesis and tumor growth in malignant melanoma cells. 

The researchers also demonstrated that Cordyceps militaris extract significantly inhibited tumor growth in culture by inducing apoptotic cell death, which is linked to the suppression of vascular endothelial growth factor receptor (VEGF) production in melanoma cells. The study concluded that Cordyceps extract could be an effective herbal medication for solid tumors. 

Another research study conducted in 2022(27) analyzed the impact of cordyceps mushrooms on skin cancer. The researchers concluded that Cordyceps mushroom reduces oxidative stress in the skin and regulates the immune T cells on the skin, thereby inhibiting metastatic melanoma invasion. 

Read More: See how Cordyceps fights cancer.

Mushroom Benefits For Skin Video

FAQs Mushroom Benefits For Skin

References

1. The Protective Role of Melanin Against UV Damage in Human Skin, (1)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671032/
2. Photoprotection and Skin Pigmentation: Melanin-Related Molecules and Some Other New Agents Obtained from Natural Sources,   (2)https://www.mdpi.com/1420-3049/25/7/1537
3. Systemic antioxidants and skin health, (3)https://pubmed.ncbi.nlm.nih.gov/23135663/ 
4. Mushrooms-Rich Preparations on Wound Healing: From Nutritional to Medicinal Attributes, (4)https://www.frontiersin.org/articles/10.3389/fphar.2020.567518/full 
5. Skin health promotion effects of natural beta-glucan derived from cereals and microorganisms: a review, (5)https://pubmed.ncbi.nlm.nih.gov/23494974/ 
6. Skin cells and tissue are capable of using L-ergothioneine as an integral component of their antioxidant defense system, (6)https://pubmed.ncbi.nlm.nih.gov/19439218/ 
7. Synergism of antifungal activity between mitochondrial respiration inhibitors and kojic acid, (7)https://pubmed.ncbi.nlm.nih.gov/23353126/ 
8. A Review of Mushrooms as a Potential Source of Dietary Vitamin D, (8)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213178/
9. Effects on tyrosinase activity by the extracts of Ganoderma lucidum and related mushrooms, (9)https://pubmed.ncbi.nlm.nih.gov/18459064/ 
10. Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum, (10)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133799/ 
11. Emerging Roles of Ganoderma Lucidum in Anti-Aging, (11)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758346/ 
12. The anti-oxidation and anti-aging effects of Ganoderma lucidum in Caenorhabditis elegans, (12)https://pubmed.ncbi.nlm.nih.gov/30476533/ 
13. Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum, (13)https://www.sciencedirect.com/science/article/pii/S1567576909002240
14. Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury, (14)https://www.mdpi.com/1424-8247/13/9/224/htm
15. Skin Cancer, (15)https://www.aad.org/media/stats-skin-cancer 
16. The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genes, (16)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735696/ 
17. The medicinal mushroom Ganoderma lucidum attenuates UV-induced skin carcinogenesis and immunosuppression, (17)https://pubmed.ncbi.nlm.nih.gov/35312729/ 
18. Diabetes mellitus and the skin, (18)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312172/ 
19. Correlation between Blood Pressure and Skin Health in Korean College Female Students, (19)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548485/
20. Hypotensive and neurometabolic effects of intragastric Reishi (Ganoderma lucidum) administration in hypertensive ISIAH rat strain, (20)https://pubmed.ncbi.nlm.nih.gov/29519314/ 
21. Bioactive compounds and bioactive properties of chaga (Inonotus obliquus) mushroom: a review, (21)http://www.isnff-jfb.com/index.php/JFB/article/view/161/290 
22. Betulinic Acid suppresses Th17 response and ameliorates psoriasis-like murine skin inflammation, (22)https://pubmed.ncbi.nlm.nih.gov/31129421/
23. Inhibitory and Acceleratory Effects of Inonotus obliquus on Tyrosinase Activity and Melanin Formation in B16 Melanoma Cells, (23)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145793/ 
24. The lifespan-extending effect of Cordyceps sinensis Cs-4 in normal mice and its molecular mechanisms, (24)https://www.researchgate.net/publication/301553051 
25. Cordyceps sinensis oral liquid prolongs the lifespan of the fruit fly, Drosophila melanogaster, by inhibiting oxidative stress, (25)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564082/ 
26. Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells, (26)https://pubmed.ncbi.nlm.nih.gov/24789042/
27. Cordyceps militaris Reduces Oxidative Stress and Regulates Immune T Cells to Inhibit Metastatic Melanoma Invasion, (27)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404731/