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< class="article__title title"> Turkey Tail Mushroom And Cancer: Breast, Colorectal, and Stomach Cancer>
Turkey Tail Mushroom And Cancer: Breast, Colorectal, and Stomach Cancer
Apr 20, 22
This article has been vetted by the Onnit Advisory Board. Read more about our editorial process.
Author: Sony Sherpa

Turkey Tail Mushroom And Cancer: Breast, Colorectal, and Stomach Cancer

    TABLE OF CONTENTS

Turkey tail mushroom has been in use for centuries in traditional Chinese medicine, where it goes by the name Yun Zhi. The extract of the fungus was used to treat respiratory ailments. In traditional western herbal medicine, it was considered to be an immunomodulator that fights infection and boosts immune function. 

Today, people are still taking advantage of the numerousturkey tail mushroom health benefits. However, in recent times, the relationship between turkey tail mushroom and cancer has come to light.

There have been some studies done on turkey tail mushroom for cancer. These turkey tail mushroom cancer studies have shown promising results. However, even though the turkey tail has been used in Japan by humans for cancer treatments for years, some people are still new to turkey tail mushrooms cancer benefits. 

In this article, we delve deeper into the scientific research on turkey tail for cancer and talk about what kind of cancer is turkey tail good for? We will also explore turkey tail mushrooms' cancer benefits and if there are any side effects.

The goal of taking a look at the turkey tail mushrooms for cancer and showing you the information that researchers in the United States have discovered during the process of analyzing turkey tail's supplements for cancer treatment purposes, we hope to move a larger number of people to holistic health solutions. Are you ready to learn more about turkey tail mushroom for cancer benefits? Read on to better understand the relationship between turkey tail mushrooms and cancer. 

What Is The Mechanism Behind Turkey Tail Cancer-Fighting Properties?

Now that you know there is a relationship between turkey tail mushroom and cancer, you may want to know how the fungi operate to eliminate or treat a variety of cancer conditions. The fact is, like many medicinal mushrooms, turkey tail mushroom contains bioactive compounds that contribute to their many health benefits. These bioactive compounds play a major role in the numerous turkey tail cancer benefits. 

Two particular polysaccharides have been extracted and isolated from the mushroom and are known to provide most of the turkey tail mushroom benefits for cancer. These are called Polysaccharide Krestin (PSK) and Polysaccharide peptide (PSP). The best turkey tail supplement for cancer carries these 2 turkey tails polysaccharides in abundance.

Preliminary research on Turkey tail mushroom cancer-fighting properties indicates that it is indeed due to PSK and PSP. Protein-bound mushroom polysaccharides like PSP and PSK stimulate the immune system(1). They encourage the body to produce more immune cells like monocytes and macrophages.  These two types of white blood cells modulate the immune system and destroy foreign and abnormal cells in the body.

Apart from inhibiting the activity of cancer cells, PSP and PSK are also thought to inhibit the mechanism of onset and progression of cancers. When a person takes advantage of the relationship between turkey tail mushrooms and cancer, the fungi help him or her with treatment—and in the event, that the person is not dealing with cancerous conditions in his life, the mushroom product or products will reduce the risk of suffering from cancer in the future.  

The spread of cancer cells and structure to other sites (or metastasis) is something all cancer patients want to prevent and avoid at all costs. However, cancer cells respond very poorly to treatment once they have migrated to distant sites. 

Turkey tail mushroom does not allow the tumor cells to spread(2). It prevents the invasion of the cancer cells by inhibiting the production of enzymes that help the process. 

For people with cancer symptoms, the vitamins and bioactive compounds in the turkey tail for cancer product do not just function to eliminate or reduce the original size of cancer—turkey tail mushroom cancer study shows that the mushroom also keeps the cancerous material from spreading to other parts of the body.  

Cancer cells attach to the blood vessel wall and form a blood clot so that they can spread throughout the body. Turkey tail prevents this vascular attachment so that it cannot spread via the bloodstream.

The mushroom polysaccharides are also believed to aid the treatment by protecting the cells from the effects of radiotherapy. PSP and PSK can reduce cancer recurrence and improve survival time.

Now that you have a better understanding of the turkey tail and cancer relationship, you may want to know how the mushroom affects different types of cancer. Can you use turkey tail mushroom for breast cancer? Can you enjoy turkey tail mushroom ovarian cancer benefits? Are there any known turkey tail brain tumor benefits? 

By taking a deeper look at the components of the turkey tail mushroom and how it helps men and women when it comes to different types of cancer, we will answer all these questions in the sections that follow. Read on to see evidence of how this nature wonder functions to improve your overall health. 

What Types Of Cancer Will Benefit From Turkey Tail Mushroom?

What Types Of Cancer Will Benefit From Turkey Tail Mushroom?

At this point, you already know the answer to questions like "is turkey tail mushroom good for cancer?". In this section, we will answer the questions "can turkey tail mushroom cure cancer?" and "does turkey tail mushroom cure cancer?"

Let’s take a look at the cancers that have shown positive responses with the use of Turkey tail polysaccharide extracts. If your doctor understands the action levels of turkey mushroom cancer, he/she may offer advice for you to use the product on the following types of cancers. 

1. Breast Cancer

When it comes to turkey mushrooms cancer, one of the major concerns is turkey tail and breast cancer. For this reason, let’s begin by talking about turkey tail mushroom and breast cancer. 

Multiple clinical and epidemiological studies suggest that immune function(3) has a role in the prevention of breast cancer.  The turkey tail breast cancer study shows that the immune-boosting polysaccharide constituents of Turkey tail mushroom can be utilized in this type of cancer.

A clinical trial(4) studying the turkey tail mushrooms breast cancer benefits has hypothesized that the mushroom improves immune response in breast cancer after receiving radiotherapy and chemotherapy. This indicates that the turkey tail mushrooms breast cancer benefits are more pronounced in cases where turkey tail mushroom chemotherapy is combined. 

The turkey tail mushrooms and breast cancer research study showed the fungi also have the potential to be used as a secondary cancer prevention strategy. This means that for women who haven't gotten a breast cancer diagnosis, taking advantage of the relationship between turkey tail mushroom and breast cancer could lower the risk of one of the most complicated diseases. 

Breast cancers are associated with unwanted estrogen production. The turkey tail mushroom breast cancer benefits have been scientifically linked to the turkey tail mushroom estrogen regulation benefits. Through detailed turkey tail mushroom cancer research, it has been found that turkey tail mushroom estrogen inhibiting effects are a result of the inhibition of aromatase(5), an enzyme that makes estrogen.

2. Colorectal Cancer

Numerous researchers have investigated the relationship between turkey tail.mushroom cancer, specifically, colorectal cancer. In one study into how adding mushrooms turkey tail mushrooms into one's nutrition impacts this condition, 63 patients with colorectal cancer were given chemotherapy with or without PSK(6). The turkey tail cancer research found that combining the polysaccharide extract improved the overall survival as well as increased the duration of relapse.

The mushroom extract was also found to inhibit the migration and invasion of colon cancer cells(7), according to a recent 2019 study. The same study also found that combining the fungal extract with chemotherapy increased the cancer-killing capacity.

Another meta-analysis evaluated 23 trials involving 10684 patients with colorectal and gastric cancer. There was a significant increase in overall survival(8) when chemotherapy was combined with the polysaccharides extract of the mushroom.

3. Stomach Cancer

A Japanese clinical trial published in 1994 suggested the clinical benefit of PSK(9) when given after the initial treatment of cancer. The study included 262 patients who had undergone resection of the stomach for gastric cancer. 

Some patients in the study received standard chemotherapy drugs while others received a combination of chemotherapy and PSK. The treatment with PSK was well tolerated by the patients and the combination chemotherapy improved the overall survival rate. Similar results(10) were also obtained from another meta-analysis.

4. Other Types Of Cancer

Research has proven that people can benefit from turkey tail mushroom lung cancer benefits. Many trials have also reported improved survival(11) in lung cancer when Turkey tail mushroom extract was combined with radiotherapy and chemotherapy. The turkey tail lung cancer study also reported that PSK exhibited direct tumor-suppressing activity as well as the suppression of the spread of the tumor.

The mushroom extract has also shown promising results(12) in treating cancers of the white blood cells (leukemia). The anti-tumors effects were due to the inhibition of the growth of cancer cells as well as the induction of cellular death.

Can You Take Turkey Tail With Chemotherapy?

Apart from the ones mentioned above, many ongoing studies continue to examine the anti-cancer potential of turkey tail mushrooms. While they certainly can’t replace anti-cancer drugs, they can be used as an adjunct in the treatment.  

Additionally, PSK has been approved by the FDA for use, as an adjunct, in cancer therapy. There is no toxicity with the combined use of PSK. When using the rightturkey tail mushroom dosage, the mushroom extract has also been shown to modulate and improve immune function during chemotherapy.

The results of the studies prove that Turkey tail can be given with chemotherapy. But does turkey tail mushroom interact with medications? Not according to the available clinical data.

Final Thoughts

Many experimental and clinical studies have evaluated the relationship between Turkey tail mushroom and cancer. The polysaccharide of the mushroom has been shown to inhibit the growth of cancer cells of the breast, the gastrointestinal tract, lungs, and white blood cells. It has also demonstrated a potent ability to kill cancer cells and prevent their spread. Incorporating Turkey tail in the chemotherapy regimen holds great potential, and could be used after a go-ahead from oncologists.

References

  1. Sekhon, B. K., Sze, D. M., Chan, W. K., Fan, K., Li, G. Q., Moore, D. E., & Roubin, R. H. (2013). PSP activates monocytes in resting human peripheral blood mononuclear cells: immunomodulatory implications for cancer treatment.Food chemistry,138(4), 2201–2209. (1) https://doi.org/10.1016/j.foodchem.2012.11.009 
  2. Kobayashi, H., Matsunaga, K., & Oguchi, Y. (1995). Antimetastatic effects of PSK (Krestin), a protein-bound polysaccharide obtained from basidiomycetes: an overview.Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology,4(3), 275–281. (2) https://pubmed.ncbi.nlm.nih.gov/7606203/ 
  3. Standish, L. J., Wenner, C. A., Sweet, E. S., Bridge, C., Nelson, A., Martzen, M., Novack, J., & Torkelson, C. (2008). Trametes versicolor mushroom immune therapy in breast cancer.Journal of the Society for Integrative Oncology,6(3), 122–128. (3) https://pubmed.ncbi.nlm.nih.gov/19087769/ 
  4. Torkelson, C. J., Sweet, E., Martzen, M. R., Sasagawa, M., Wenner, C. A., Gay, J., Putiri, A., & Standish, L. J. (2012). Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer.ISRN oncology,2012, 251632. (4) https://doi.org/10.5402/2012/251632 
  5. Archives Agaricus sylvaticus. (n.d.). Clinics. Retrieved June 10, 2022, from (5) https://www.clinicsjournal.com/article-keyword/agaricus-sylvaticus/ 
  6. Yoshitani, S., & Takashima, S. (2009). Efficacy of postoperative UFT (Tegafur/Uracil) plus PSK therapies in elderly patients with resected colorectal cancer.Cancer biotherapy & radiopharmaceuticals,24(1), 35–40. (6) https://doi.org/10.1089/cbr.2008.0547 
  7. Roca-Lema, D., Martinez-Iglesias, O., Fernández de Ana Portela, C., Rodríguez-Blanco, A., Valladares-Ayerbes, M., Díaz-Díaz, A., Casas-Pais, A., Prego, C., & Figueroa, A. (2019).In Vitro Anti-proliferative and Anti-invasive Effect of Polysaccharide-rich Extracts fromTrametes Versicolor and Grifola Frondosa in Colon Cancer Cells.International journal of medical sciences,16(2), 231–240. (7) https://doi.org/10.7150/ijms.28811 
  8. Ma, Y., Wu, X., Yu, J., Zhu, J., Pen, X., & Meng, X. (2017). Can polysaccharide K improve therapeutic efficacy and safety in gastrointestinal cancer? a systematic review and network meta-analysis.Oncotarget,8(51), 89108–89118. (8) https://doi.org/10.18632/oncotarget.19059 
  9. Nakazato, H., Koike, A., Saji, S., Ogawa, N., & Sakamoto, J. (1994). Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study Group of Immunochemotherapy with PSK for Gastric Cancer.Lancet (London, England),343(8906), 1122–1126. (9) https://doi.org/10.1016/s0140-6736(94)90233-x 
  10. Oba, K., Teramukai, S., Kobayashi, M., Matsui, T., Kodera, Y., & Sakamoto, J. (2007). Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cancer.Cancer immunology, immunotherapy : CII,56(6), 905–911. (10) https://doi.org/10.1007/s00262-006-0248-1 
  11. Fritz, H., Kennedy, D. A., Ishii, M., Fergusson, D., Fernandes, R., Cooley, K., & Seely, D. (2015). Polysaccharide K and Coriolus versicolor extracts for lung cancer: a systematic review.Integrative cancer therapies,14(3), 201–211. (11) https://doi.org/10.1177/1534735415572883 
  12. HSIEH, T.-C., & WU, J. M. (2013). Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by the combination of Coriolus versicolor and Ganoderma lucidum. International Journal of Molecular Medicine,32(1), 251–257. (12) https://doi.org/10.3892/ijmm.2013.1378
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